Prof. Alexandre Douplik Profile

Prof. Alexandre Douplik

Physics Professor, Head of Ryerson Photonics Group at Toronto Metropolitan University

SPIE Involvement:

Author | Student Chapter Advisor | Science Fair Judge

Area of Expertise:

Biophotonics , Medical Physics

Websites:

Personal Website

Profile Summary

Dr. Alexandre (Sasha) Douplik is a Professor, Head of Ryerson Photonics Group in Physics Department at Ryerson University since 2011, and a Scientist of St. Michael’s Hospital, Toronto, specialized in Advanced Optical Biomedical Imaging and Laser Surgery and Therapy, the author of more than 60 peer-reviewed papers, 70 conference papers, 6 book chapters and 15 patents. In 2008-2011 he was a contract (non-tenure-track) Research Professor/Habilitant of Nuremberg-Erlangen University, Germany where he defended his Biomedical Engineering Habilitation (Dr. of Science degree) in 2011. Before 2007 Dr. Douplik was a Scientific Associate at Biophysics/Bioimaging Division in Ontario Cancer Institute in Toronto (2006-2007) and Senior Researcher of Xillix Technologies Corp., Vancouver (2002-2006).

Publications (38)

Proceedings Article | 4 October 2023 Poster + Paper

Poster + Paper

Remote physiological monitoring of neck blood vessels

Meiyun Cao, Gennadi Saiko, Timothy Burton, Alexandre Douplik

Proceedings Volume 12673, 126730R (2023) https://doi.org/10.1117/12.2680679

KEYWORDS: Neck, Chemical vapor deposition, Cameras, Signal filtering, Tunable filters, Pulse signals, Arteries, MATLAB, Electronic filtering, Skin

Read Abstract +

Proceedings Article | 22 July 2019 Paper

Paper

Surface Enhanced Raman Spectroscopy (SERS) optical fibers for remote sensing

Aditya Pandya, J. Carl Kumaradas, Alexandre Douplik

Proceedings Volume 11075, 1107506 (2019) https://doi.org/10.1117/12.2527175

KEYWORDS: Optical fibers, Surface enhanced Raman spectroscopy, Remote sensing, Silica, Raman spectroscopy, Fabrication, Glasses, Optical spheres, Optical filters, Luminescence

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Proceedings Article | 18 January 2018 Paper

Paper

Holographic interferometry imaging monitoring of photodynamic (PDT) reactions in gelatin biophantom

N. Davidenko, H. Mahdi, X. Zheng, I. Davidenko, V. Pavlov, N. Kuranda, N. Chuprina, S. Studzinsky, A. Pandya, H. Karia, S. Tajouri, M. Dervenis, C. Gergely, A. Douplik

Proceedings Volume 10612, 106120H (2018) https://doi.org/10.1117/12.2305576

KEYWORDS: Photodynamic therapy, Holography, Oxygen, Holographic interferometry, Blood, Absorption, Refractive index, Video, Tissues, Laser irradiation

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Proceedings Article | 3 March 2017 Paper

Paper

Photoacoustic measurements of red blood cell oxygen saturation in blood bags in situ

Ruben Pinto, Karan Bagga, Alexandre Douplik, Jason Acker, Michael Kolios

Proceedings Volume 10064, 1006440 (2017) https://doi.org/10.1117/12.2253530

KEYWORDS: In situ remote sensing, Photoacoustic imaging, Blood, Photoacoustic spectroscopy, Oxygen, Blood oxygen saturation, Oximetry, Functional imaging, In situ metrology, In vitro testing, Gold, Medicine, Standards development, Transducers

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SPIE Journal Paper | 28 July 2016 Open Access

Open Access

Microvascular contrast enhancement in optical coherence tomography using microbubbles

Homa Assadi, Valentin Demidov, Raffi Karshafian, Alexandre Douplik, I. Alex Vitkin

JBO, Vol. 21, Issue 07, 076014, (July 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.7.076014

KEYWORDS: Blood, Optical coherence tomography, Blood circulation, Tissues, Scattering, Speckle, In vivo imaging, Visualization, Particles, Ultrasonography

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Proceedings Article | 22 April 2016 Presentation + Paper

Presentation + Paper

Plasma dispersion effect assisted nanoscopy based on tuning of absorption and scattering resonances of nanoparticles

Yossef Danan, Tali Ilovitsh, Danping Liu, Hadar Pinhas, Moshe Sinvani, Yehonatan Ramon, Jonathan Azougi, Alexandre Douplik, Zeev Zalevsky

Proceedings Volume 9721, 97210J (2016) https://doi.org/10.1117/12.2210800

KEYWORDS: Nanoparticles, Absorption, Scattering, Silicon, Plasma, Light scattering, Super resolution microscopy, Medical diagnostics, Coating, Gold, Point spread functions, Refractive index

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Proceedings Article | 4 March 2016 Paper

Paper

Blood flow contrast enhancement in optical coherence tomography using microbubbles: a phantom study

Homa Assadi, Valentin Demidov, Raffi Karshafian, Alexandre Douplik, I. Alex Vitkin

Proceedings Volume 9715, 97151F (2016) https://doi.org/10.1117/12.2211665

KEYWORDS: Optical coherence tomography, Blood, Speckle, Tissues, Scattering, Blood circulation, Visualization, In vivo imaging, Gold, Particles

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SPIE Journal Paper | 14 January 2016 Open Access

Open Access

Spatially resolved, diffuse reflectance imaging for subsurface pattern visualization toward development of a lensless imaging platform: phantom experiments

Irina Schelkanova, Aditya Pandya, Guennadi Saiko, Lidia Nacy, Hannan Babar, Duoaud Shah, Lothar Lilge, Alexandre Douplik

JBO, Vol. 21, Issue 01, 015004, (January 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.1.015004

KEYWORDS: Scattering, Diffuse reflectance spectroscopy, Sensors, Microfluidics, Fiber optics, Imaging systems, Visualization, Absorption, Silicon, Raster graphics

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Proceedings Article | 15 July 2015 Paper

Paper

Evaluation of spatially resolved diffuse reflectance imaging for subsurface pattern visualization towards applicability for fiber optic lensless imaging setup: phantom experiments and simulation

I. Schelkanova, A. Pandya, G. Saiko, L. Nacy, H. Babar, D. Shah, L. Lilge, A. Douplik

Proceedings Volume 9537, 95371T (2015) https://doi.org/10.1117/12.2183828

KEYWORDS: Scattering, Sensors, Fiber optics, Microfluidics, Diffuse reflectance spectroscopy, Visualization, Capillaries, Spatial resolution, Absorption, Fiber optics sensors

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Proceedings Article | 5 March 2015 Paper

Paper

Study optical properties of biological tissue in the presence of microbubbles

Homa Assadi, Vincent Lee, Raffi Karshafian, Alexandre Douplik

Proceedings Volume 9321, 93210X (2015) https://doi.org/10.1117/12.2075673

KEYWORDS: Blood, Tissue optics, Scattering, Optical properties, Light scattering, Diffuse reflectance spectroscopy, Transmittance, Absorption, Soft tissue optics, Spectroscopy

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Proceedings Article | 3 March 2014 Paper

Paper

Three-dimensional tracking of lesion profile during laser surgery based on shock wave detection

Erwin Bay, Xosé Luis Dean Ben, Genny Pang, Alexandre Douplik, Daniel Razansky

Proceedings Volume 8943, 89431N (2014) https://doi.org/10.1117/12.2040376

KEYWORDS: Sensors, Laser therapeutics, Laser ablation, Tissues, Laser tissue interaction, Pulsed laser operation, Detector arrays, Laser cutting, Ultrasonics, Optical tracking

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Proceedings Article | 4 March 2013 Paper

Paper

Optoacoustic monitoring of cutting and heating processes during laser ablation

Erwin Bay, Alexandre Douplik, Daniel Razansky

Proceedings Volume 8581, 85813X (2013) https://doi.org/10.1117/12.2005027

KEYWORDS: Tissues, Laser ablation, Laser cutting, Laser tissue interaction, Tissue optics, Laser therapeutics, Natural surfaces, Signal detection, Transducers, Absorption

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SPIE Journal Paper | 2 November 2012 Open Access

Open Access

Refractive index of solutions of human hemoglobin from the near-infrared to the ultraviolet range: Kramers-Kronig analysis

Oleksiy Sydoruk, Olga Zhernovaya, Valery Tuchin, Alexandre Douplik

JBO, Vol. 17, Issue 11, 115002, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.115002

KEYWORDS: Refractive index, Water, Absorption, Ultraviolet radiation, Blood, Biomedical optics, Glucose, Sodium, Visible radiation, Optical properties

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Proceedings Article | 17 June 2011 Paper

Paper

Preliminary results for hyperspectral videoendoscopy diagnostics on the phantoms of normal and abnormal tissues: towards gastrointestinal diagnostics

Martin Hohmann, Alexandre Douplik, Janani Varadhachari, Aulia Nasution, Jonas Mudter, Markus Neurath, Michael Schmidt

Proceedings Volume 8087, 80872N (2011) https://doi.org/10.1117/12.889829

KEYWORDS: Tissues, Reflectivity, Endoscopes, Cancer, Video, Diagnostics, Endoscopy, Tumors, Titanium, Oxides

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Proceedings Article | 22 February 2011 Paper

Paper

In vivo monitoring of vessel density pattern in skin phantoms for the application of early sign of shock detection by using diffuse reflectance spectroscopy

Rajesh Kanawade, Gennadi Sayko, Michael Schmidt, Alexandre Douplik

Proceedings Volume 7890, 789009 (2011) https://doi.org/10.1117/12.874208

KEYWORDS: Diffuse reflectance spectroscopy, Capillaries, Sensors, Skin, Tissue optics, Blood, Light sources, Optical properties, Absorption, Ocean optics

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Proceedings Article | 23 February 2010 Paper

Paper

Tissue differentiation by diffuse reflectance spectroscopy for automated oral and maxillofacial laser surgery: ex vivo pilot study

Azhar Zam, Florian Stelzle, Katja Tangermann-Gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik

Proceedings Volume 7555, 755516 (2010) https://doi.org/10.1117/12.841674

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Bone, Laser therapeutics, Nerve, Tissue optics, Surgery, Laser tissue interaction, Ocean optics, Haptic technology

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Proceedings Article | 10 July 2009 Paper

Paper

Enhancement of cancerous/normal tissue contrast via combined white light and fluorescence image processing: initial investigation ex vivo

Angelos Kalitzeos, Azhar Zam, Florian Stelzle, Eckhart Hahn, Martin Raithel, Alexandre Douplik

Proceedings Volume 7371, 73710N (2009) https://doi.org/10.1117/12.831771

KEYWORDS: Tissue optics, Luminescence, Endoscopy, Image processing, Tissues, Cameras, Image enhancement, Cancer, Reflectivity, Video

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Proceedings Article | 10 July 2009 Paper

Paper

Monitoring of epithelium capillary density

Rajesh Kanawade, Gennadiy Saiko, Alexandre Douplik

Proceedings Volume 7371, 73711L (2009) https://doi.org/10.1117/12.831725

KEYWORDS: Capillaries, Modulation, Sensors, Rhodamine B, Diffuse reflectance spectroscopy, Blood, Absorption, Signal attenuation, Signal processing, Scattering

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Proceedings Article | 8 July 2009 Paper

Paper

Soft tissue differentiation by diffuse reflectance spectroscopy

Azhar Zam, Florian Stelzle, Emeka Nkenke, Katja Tangermann-Gerk, Michael Schmidt, Werner Adler, Alexandre Douplik

Proceedings Volume 7368, 736821 (2009) https://doi.org/10.1117/12.831616

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Tissue optics, Laser therapeutics, Nerve, Surgery, Laser tissue interaction, Skin, Laser ablation, Ocean optics

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SPIE Journal Paper | 1 July 2009 Open Access

Open Access

Feasibility study of autofluorescence mammary ductoscopy

Alexandre Douplik, Wey-Liang Leong, Alexandra Easson, S. Done, George Netchev, Brian Wilson

JBO, Vol. 14, Issue 04, 044036, (July 2009) https://doi.org/10.1117/12.10.1117/1.3210773

KEYWORDS: Tissues, Luminescence, Tumors, Tissue optics, Imaging spectroscopy, Diffuse reflectance spectroscopy, Reflectivity, Cancer, Spectroscopy, Algorithm development

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SPIE Journal Paper | 1 March 2009 Open Access

Open Access

Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers

David Rioux, Marie Laferrière, Alexandre Douplik, Duoaud Shah, Lothar Lilge, Andrei Kabashin, Michel Meunier

JBO, Vol. 14, Issue 02, 021010, (March 2009) https://doi.org/10.1117/12.10.1117/1.3086608

KEYWORDS: Nanoparticles, Silicon, Laser ablation, Semiconductor lasers, Oxygen, Femtosecond phenomena, Laser therapeutics, Toxicity, Photoacoustic tomography, Picosecond phenomena

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Proceedings Article | 15 April 2005 Paper

Paper

A method to improve the reproducibility of in vivo reflectance spectroscopy

Alexandre Douplik, David Shalaby, Brian Wilson, Joseph Perry

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.596427

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Natural surfaces, Tissue optics, In vivo imaging, Reflectivity, Spectroscopy, Endoscopy, Blood, Reflectance spectroscopy

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SPIE Journal Paper | 1 July 2000 Open Access

Open Access

Study of photodynamic reactions in human blood

Alexandre Douplik, Alexander Stratonnikov, Victor Loschenov, Victoria Lebedeva, Valentina Derkacheva, I. Alex Vitkin, V. Rumyanceva, S. Kusmin, Andrei Mironov, Eugeny Lukyanets

JBO, Vol. 5, Issue 03, (July 2000) https://doi.org/10.1117/12.10.1117/1.430005

KEYWORDS: Blood, Luminescence, Oxygen, Chlorine, Photodynamic therapy, Zinc, Tissues, In vitro testing, Blood oxygen saturation, Absorption

Proceedings Article | 19 May 1998 Paper

Paper

Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy

Alexander Stratonnikov, Alexandre Douplik, D. Klimov, Victor Loschenov, S. Mizin

Proceedings Volume 3247, (1998) https://doi.org/10.1117/12.308140

KEYWORDS: Photodynamic therapy, Oxygen, Blood, Blood oxygen saturation, Laser irradiation, In vivo imaging, Absorption, In vitro testing, Tissue optics, Switching

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Proceedings Article | 13 May 1998 Paper

Paper

Oxygen consumption during photodynamic reactions in human blood

Alexandre Douplik, Victor Loschenov, Victoria Lebedeva, Valentina Derkacheva, V. Rumyanceva, L. Chasovnikova, S. Kusmin, Andrei Mironov, Eugeny Lukyanets, V. Sergienko

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308197

KEYWORDS: Blood, Oxygen, Chlorine, Zinc, In vitro testing, Glasses, Photodynamic therapy, Statistical analysis, Tissues, Molecules

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Proceedings Article | 13 January 1998 Paper

Paper

New method of fluorescence diagnostics, photodynamic preventive maintenance, and treatment of diseases of the periodontium and mucous membrane of mouth

Alexandre Douplik, Victor Loschenov, D. Klimov, Kirill Linkov

Proceedings Volume 3196, (1998) https://doi.org/10.1117/12.297934

KEYWORDS: Diagnostics, Luminescence, Mouth, Photodynamic therapy

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Proceedings Article | 29 December 1997 Paper

Paper

Absorption spectroscopy as a tool to control blood oxygen saturation during photodynamic therapy

Alexander Stratonnikov, Alexandre Douplik, D. Klimov, Victor Loschenov, Gennadii Meerovich, S. Mizin, Galina Fomina, Natalia Kazachkina, Raisa Yakubovskaya, Yu. Budenok

Proceedings Volume 3191, (1997) https://doi.org/10.1117/12.297831

KEYWORDS: Photodynamic therapy, Oxygen, Blood oxygen saturation, Absorption spectroscopy, Cancer, Tissue optics, Molecular interactions

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Proceedings Article | 29 December 1997 Paper

Paper

Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids cancer cells using sulphonated phthalocyanine aluminum photosensitizer

Alexandre Douplik, Victor Loschenov, Georgy Vorozhtsov, Eugenia Kogan, Michael Kusin, Y. Ablitsov, O. Ilyina

Proceedings Volume 3191, (1997) https://doi.org/10.1117/12.297793

KEYWORDS: Cell death, Liquids, Cancer, Aluminum, Oncology, Light sources, Analytical research, Photodynamic therapy

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Proceedings Article | 18 August 1997 Paper

Paper

Noninvasive investigation of skin local hypothermia influence upon local oxygenation and hemoglobin concentration

Alexandre Douplik, Manfred Kessler, Yasuyuki Kakihana, Alfons Krug

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280267

KEYWORDS: Skin, Photodynamic therapy, Tissue optics, Blood, Laser tissue interaction, In vivo imaging, Spectroscopy, Tissues, Scattering, Visible radiation

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Proceedings Article | 18 August 1997 Paper

Paper

Stable and reliable measurement of intracapillary hemoglobin-oxygenation in human skin by EMPHO II

Yasuyuki Kakihana, Manfred Kessler, Alexandre Douplik, Alfons Krug

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280268

KEYWORDS: Skin, Oxygen, Ischemia, Tissues, Blood circulation, Temperature metrology, Reliability, Sensors, Spectrophotometry, Hypoxia

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Proceedings Article | 5 December 1996 Paper

Paper

Changes of optical parameters of moving whole blood depending on shear rate

Alexandre Douplik, Victor Loschenov, Vladislav Malinin, S. Proscurnev, D. Klimov

Proceedings Volume 2923, (1996) https://doi.org/10.1117/12.260748

KEYWORDS: Blood, Absorption, Blood circulation, Scattering, Light scattering, Modulation, Laser scattering, Monte Carlo methods, Reflection, Medicine

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Proceedings Article | 5 December 1996 Paper

Paper

Spectra changes of whole blood with sulphonated aluminum phtalocyanine photosensitizer during photodynamic therapy in vitro

Alexandre Douplik, Victor Loschenov, Alexander Stratonnikov

Proceedings Volume 2923, (1996) https://doi.org/10.1117/12.260747

KEYWORDS: Blood, Oxygen, In vitro testing, Photodynamic therapy, Aluminum, Laser irradiation, Proteins, Laser scattering, Statistical analysis, Tissue optics

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Proceedings Article | 10 May 1996 Paper

Paper

Identification of optical parameters of the whole blood depending on its oxygenation level

Alexandre Douplik, Victor Loschenov

Proceedings Volume 2678, (1996) https://doi.org/10.1117/12.239546

KEYWORDS: Blood, Scattering, Absorption, Optical properties, In vitro testing, Diffuse reflectance spectroscopy, Integrating spheres, Time metrology, Monte Carlo methods, Spectrophotometry

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Proceedings Article | 10 January 1996 Paper

Paper

Identification of spectroscopic and optical parameters of whole blood depending on its concentration and layer thickness

Alexandre Douplik, Victor Loschenov

Proceedings Volume 2624, (1996) https://doi.org/10.1117/12.229550

KEYWORDS: Blood, Scattering, Absorption, Light scattering, Signal attenuation, Laser scattering, Monte Carlo methods, Diffuse reflectance spectroscopy, Photons, Laser therapeutics

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Proceedings Article | 31 January 1995 Paper

Paper

Identification of spectroscopic parameters of whole blood depending on its physiological properties

Alexandre Douplik, Ilya Yaroslavsky, Victor Loschenov, M. Alexandrov, Abram Sirkin

Proceedings Volume 2326, (1995) https://doi.org/10.1117/12.200835

KEYWORDS: Blood, Scattering, Optical properties, Diffuse reflectance spectroscopy, Laser tissue interaction, Oxygen, Particles, Spectroscopy, In vivo imaging, Integrating spheres

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Proceedings Article | 12 January 1995 Paper

Paper

Investigation of phtalocyanine Al photosensitizer and blood interaction

Nadezgda Torshina, Victor Loschenov, Alexander Stratonnikov, Alexandre Douplik, Anna Posypanova

Proceedings Volume 2325, (1995) https://doi.org/10.1117/12.199174

KEYWORDS: Blood, Aluminum, Photodynamic therapy, Laser therapeutics, Absorption, Spectroscopy, Spectrophotometry, Oxygen, Laser irradiation, Integrating spheres

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Proceedings Article | 15 February 1994 Paper

Paper

Use of the concept of "specific power density" for parametrization of low-level laser irradiation

Alexandre Douplik

Proceedings Volume 2086, (1994) https://doi.org/10.1117/12.169103

KEYWORDS: Optical properties, Blood, Tissue optics, Picosecond phenomena, Scattering, Laser irradiation, Laser scattering, Biomedical optics, Tissues, Light scattering

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Proceedings Article | 2 June 1993 Paper

Paper

Calculation of specific power density of blood for intravenous low-level laser therapy

Alexandre Douplik, Y. Gordeev, Ilya Yaroslavsky

Proceedings Volume 1981, (1993) https://doi.org/10.1117/12.146474

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Showing 5 of 38 publications

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