Prof. E. Duco Jansen Profile

Prof. E. Duco Jansen

Professor of Biomedical Engineering at Vanderbilt Univ

SPIE Involvement:

Conference Program Committee | Track Chair | Author | Editor

Publications (86)

SPIE Journal Paper | 6 September 2024 Open Access

Impact of scattering phase function and polarization on the accuracy of diffuse and sub-diffuse spatial frequency domain imaging

Alec Walter, E. Duco Jansen

JBO, Vol. 29, Issue 09, 095001, (September 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.9.095001

KEYWORDS: Scattering, Reflectivity, Optical properties, Polarization, Absorption, Spatial frequencies, Zinc oxide, Backscatter, Photons, Monte Carlo methods

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SignificanceAlthough spatial frequency domain imaging (SFDI) has been well characterized under diffuse optical conditions, tissue measurements made outside the diffuse regime can provide new diagnostic information. Before such measurements can become clinically relevant, however, the behavior of sub-diffuse SFDI and its effect on the accuracy of derived tissue parameters must be assessed.AimWe aim to characterize the impact that both the assumed scattering phase function (SPF) and the polarization state of the illumination light source have on the accuracy of SFDI-derived optical properties when operating under diffuse or sub-diffuse conditions, respectively.ApproachThrough the use of a set of well-characterized optical phantoms, SFDI accuracy was assessed at four wavelengths (395, 545, 625, and 850 nm) and two different spatial frequencies (0.3 and 1.0 mm−1), which provided a broad range of diffuse and sub-diffuse conditions, using three different SPFs. To determine the effects of polarization, the SFDI accuracy was assessed using both unpolarized and cross-polarized illumination.ResultsIt was found that the assumed SPF has a direct and significant impact on the accuracy of the SFDI-derived optical properties, with the best choice of SPF being dictated by the polarization state. As unpolarized SFDI retains the sub-diffuse portion of the signal, optical properties were found to be more accurate when using the full SPF that includes forward and backscattering components. By contrast, cross-polarized SFDI yielded accurate optical properties when using a forward-scattering SPF, matching the behavior of cross-polarization to attenuate the immediate backscattering of sub-diffuse reflectance. Using the correct pairings of SPF and polarization enabled using a reflectance standard, instead of a more subjective phantom, as the reference measurement.ConclusionsThese results provide the foundation for a more thorough understanding of SFDI and enable new applications of this technology in which sub-diffuse conditions dominate (e.g., μa≮μs′) or high spatial frequencies are required.

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Proceedings Article | 13 March 2024 Presentation

Varying laser pulse widths influence infrared neural stimulation efficacy in vitro

Jacob Hardenburger, Bryan Gamboa, Joel Bixler, Christopher Valdez, Bryan Millis, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 12829, 1282905 (2024) https://doi.org/10.1117/12.3004830

KEYWORDS: In vitro testing, Infrared radiation, Pulsed laser operation, Pulse signals, Neurons, Calcium, Infrared imaging, Optical fibers, Nervous system, Microscopes

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Proceedings Article | 6 March 2023 Presentation

Epoxy resin tissue phantoms with spectra-fitted optical properties for broadband and multiband applications

Alec Walter, E. Duco Jansen

Proceedings Volume PC12370, PC1237004 (2023) https://doi.org/10.1117/12.2667146

KEYWORDS: Optical properties, Tissues, Epoxies, Pigments, Skin, Reflectance spectroscopy, Process modeling, Spectroscopy, Spectrophotometry, Scattering

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SPIE Journal Paper | 20 February 2023 Open Access

Development of a platform for broadband, spectra-fitted, tissue optical phantoms

Alec Walter, E. Duco Jansen

JBO, Vol. 28, Issue 02, 025001, (February 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.2.025001

KEYWORDS: Pigments, Absorption, Tissues, Optical properties, Scattering, Diffuse reflectance spectroscopy, Skin, Optical phantoms, Light absorption, Epoxies

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Proceedings Article | 7 March 2022 Presentation

Selective IR inhibition can be reproduced by resistance heating

Junqi Zhuo, Chloe Weidrick, Yehe Liu, Michael Moffitt, E. Jansen, Hillel Chiel, Michael Jenkins

Proceedings Volume PC11947, PC1194706 (2022) https://doi.org/10.1117/12.2610130

KEYWORDS: Resistance, Nerve, Axons, In vitro testing, Temperature metrology, Sensors, Potassium, Optical fibers, Infrared radiation, Electrodes

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Proceedings Article | 7 March 2022 Presentation

Computational modeling of photomechanical effects during infrared neural stimulation

Mayna Nguyen, Chad Oian, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume PC11947, PC1194707 (2022) https://doi.org/10.1117/12.2607633

KEYWORDS: Infrared radiation, Infrared photography, Computational modeling

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Proceedings Article | 7 March 2022 Presentation

Combined fluorescence and spatial frequency domain imaging to monitor photodynamic therapy dosimetry throughout treatment

Alec Walter, Ezekiel Haugen, E. Duco Jansen

Proceedings Volume PC11958, PC1195804 (2022) https://doi.org/10.1117/12.2613608

KEYWORDS: Photodynamic therapy, Luminescence, Optical properties, Imaging systems, Tissues, Tissue optics, Temporal resolution, Oxygen, Measurement devices, Calibration

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Proceedings Article | 7 March 2022 Presentation

Comparing electrical and infrared neural stimulation for intraoperative nerve monitoring

Graham Throckmorton, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume PC11947, PC1194702 (2022) https://doi.org/10.1117/12.2607512

KEYWORDS: Nerve, Infrared radiation, Injuries, Tissue optics, Surgery, Performance modeling, In vivo imaging, Genetics, Damage detection, Axons

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SPIE Journal Paper | 31 March 2021 Open Access

Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system

Graham Throckmorton, Jonathan Cayce, Zane Ricks, Wilson Adams, E. Duco Jansen, Anita Mahadevan-Jansen

NPh, Vol. 8, Issue 01, 015012, (March 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015012

KEYWORDS: Semiconductor lasers, Nerve, Infrared radiation, Pulsed laser operation, Diodes, Safety, Neurophotonics, Laser damage threshold, Laser systems engineering, Absorption

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Proceedings Article | 5 March 2021 Presentation

Laser-induced heating modulates microglial calcium signaling

John Logan Jenkins, Wilson Adams, Jeremy Ford, Sam Evans, Anita Mahadevan-Jansen, Mark Hutchinson, Duco Jansen

Proceedings Volume 11629, 1162913 (2021) https://doi.org/10.1117/12.2588775

KEYWORDS: Calcium, Modulation, Cell death, Infrared radiation, Pulsed laser operation, Optical fibers, Nervous system, Microscopy, Luminescence, Forward looking infrared

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SPIE Journal Paper | 19 February 2021 Open Access

Isotonic ion replacement can lower the threshold for selective infrared neural inhibition

Junqi Zhuo, Zihui Ou, Yuhan Zhang, Elizabeth Jackson, Sachin Shankar, Matthew McPheeters, Jeremy Ford, E. Duco Jansen, Hillel Chiel, Michael Jenkins

NPh, Vol. 8, Issue 01, 015005, (February 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015005

KEYWORDS: Ions, Glucose, Nerve, Infrared radiation, Temperature metrology, Axons, Neurophotonics, Thermography, Systems modeling, Potassium

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Proceedings Article | 10 March 2020 Presentation

Effects of 690nm light on the response of Staphylococcus aureus to oxidative stress (Conference Presentation)

Alec Walter, Eric Skaar, E. Duco Jansen

Proceedings Volume 11221, 1122108 (2020) https://doi.org/10.1117/12.2544401

KEYWORDS: Modulation, Oxygen, Bacteria, In vitro testing, Photodynamic therapy, Hydrogen

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Proceedings Article | 10 March 2020 Presentation

Probing the mechanisms of infrared neural stimulation with stimulated Raman scattering microscopy (Conference Presentation)

Wilson Adams, Rekha Gautam, Graham Throckmorton, Laura Masson, Jeremy Ford, John Logan Jenkins, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 11252, 1125204 (2020) https://doi.org/10.1117/12.2545228

KEYWORDS: Infrared radiation, Raman scattering, Infrared imaging, Microscopy, Raman spectroscopy, Imaging spectroscopy, Spectroscopy, Electrodynamics, Infrared signatures, Physiology

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Proceedings Article | 9 March 2020 Presentation

Astrocyte sensitivity to pulsed infrared light: molecular, physiological, and mechanistic insights (Conference Presentation)

Wilson Adams, Ana Borrachero-Conejo, Emanuela Saracino, Manqing Wang, Tamara Posati, Graham Throckmorton, John Logan Jenkins, Jeremy Ford, Roberto Zamboni, Marco Caprini, Grazia Paola Nicchia, E. Duco Jansen, Valentina Benfenati, Anita Mahadevan-Jansen

Proceedings Volume 11227, 112270N (2020) https://doi.org/10.1117/12.2545237

KEYWORDS: Infrared radiation, Infrared imaging, Thermography, Brain, Calcium, Receptors, Luminescence, Proteins, In vitro testing, Short wave infrared radiation

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Proceedings Article | 9 March 2020 Presentation

Assessment of variable block lengths during infrared neural inhibition (Conference Presentation)

Jeremy Ford, Michael Jenkins, Hillel Chiel, E. Duco Jansen

Proceedings Volume 11227, 112270M (2020) https://doi.org/10.1117/12.2542543

KEYWORDS: Infrared radiation, Nerve, Action potentials, Infrared lasers, Absorption, Axons, Modulation, Tissues, Tissue optics, Cameras

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Proceedings Article | 9 March 2020 Presentation

Computational and experimental evaluation of the mechanism of infrared neural inhibition in aplysia (Conference Presentation)

Jeremy Ford, Mohit Ganguly, Junqi Zhuo, Matthew McPheeters, Michael Jenkins, Hillel Chiel, E. Duco Jansen

Proceedings Volume 11227, 112270P (2020) https://doi.org/10.1117/12.2546879

KEYWORDS: Infrared radiation, Potassium, Axons, Neurons, Computer simulations, Optical fibers, Ions, Computational modeling, Optical simulations, In vitro testing

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Proceedings Article | 9 March 2020 Presentation

Comparing the efficacy of infrared diode and Ho:YAG lasers for infrared neural stimulation (Conference Presentation)

Graham Throckmorton, Wilson Adams, Zane Ricks, Jonathan Cayce, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 11227, 112270R (2020) https://doi.org/10.1117/12.2546270

KEYWORDS: Semiconductor lasers, Infrared radiation, Diodes, Infrared lasers, Laser damage threshold, Tissue optics, Animal model studies, Pulsed laser operation, In vivo imaging, Nerve

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SPIE Journal Paper | 15 October 2019 Open Access

Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study

Mohit Ganguly, Jeremy Ford, Junqi Zhuo, Matthew McPheeters, Michael Jenkins, Hillel Chiel, E. Duco Jansen

NPh, Vol. 6, Issue 04, 040501, (October 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.4.040501

KEYWORDS: Potassium, Nerve, Ion channels, Action potentials, Axons, Infrared radiation, Thermography, Sodium, Optical fibers, Infrared lasers

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Proceedings Article | 8 March 2019 Open Access

30 years of Laser-Tissue Interaction and beyond

E. Duco Jansen

Proceedings Volume 10876, 1087611 (2019) https://doi.org/10.1117/12.2525152

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Proceedings Article | 7 March 2019 Presentation

Comparing infrared neuromodulation (IRN) with isotonic glucose solution for selective inhibition of small-diameter axons (Conference Presentation)

Junqi Zhuo, Matthew McPheeters, Elizabeth Jackson, Sachin Shankar, Mohit Ganguly, E. Jansen, Hillel Chiel, Michael Jenkins

Proceedings Volume 10866, 108660O (2019) https://doi.org/10.1117/12.2510417

KEYWORDS: Glucose, Axons, Infrared radiation, Nerve, Heart, Failure analysis, Clinical trials, Modulation, Mathematics, Action potentials

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Proceedings Article | 7 March 2019 Presentation

Comparing the efficacy and safety of infrared neural stimulation at 1450 nm and 1875 nm (Conference Presentation)

Graham Throckmorton, Wilson Adams, Zane Ricks, Jonathan Cayce, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 10866, 108660G (2019) https://doi.org/10.1117/12.2508055

KEYWORDS: Safety, Infrared radiation, Tissues, Genetics, Laser energy, Action potentials, In vivo imaging, Nerve, Clinical research

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Proceedings Article | 4 March 2019 Presentation

Increasing the efficacy of antimicrobial photodynamic therapy through the simultaneous activation of multiple coproporphyrin III absorption peaks (Conference Presentation)

Alec Walter, Jocelyn Simpson, J. Logan Jenkins, Dennis Hovarth, Eric Skaar, E. Duco Jansen

Proceedings Volume 10863, 108630R (2019) https://doi.org/10.1117/12.2508678

KEYWORDS: Photodynamic therapy, Absorption, In vivo imaging, In vitro testing, Oxygen, Bacteria, Resistance, Skin, Light sources

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Proceedings Article | 14 March 2018 Presentation

Excitability of astrocyte in vitro with infrared neural stimulation (Conference Presentation)

Wilson Adams, Manqing Wang, Ana Borrachero-Conejo, Emanuela Saracino, Roberto Zamboni, Valentina Benfenati, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 10482, 104820D (2018) https://doi.org/10.1117/12.2291246

KEYWORDS: Infrared imaging, Infrared radiation, Calcium, Transient nonlinear optics, Brain, Thermography, In vivo imaging, In vitro testing, Modulation, Neurophotonics

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Proceedings Article | 19 April 2017 Presentation

Analysis of components of compound action potentials in response to infrared laser light (Conference Presentation)

Junqi Zhuo, Emilie Lothet, E. Duco Jansen, Charles Horn, Hillel Chiel, Michael Jenkins

Proceedings Volume 10052, 100520N (2017) https://doi.org/10.1117/12.2253275

KEYWORDS: Current controlled current source, Action potentials, Modulation, Infrared radiation, Nerve, Infrared lasers, Numerical simulations, Destructive interference, Optogenetics, Optical manipulation

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Proceedings Article | 30 March 2017 Paper

Neural responses of rat cortical layers due to infrared neural modulation and photoablation of thalamocortical brain slices

J. Logan Jenkins, Chris Kao, Jonathan Cayce, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 10052, 100520L (2017) https://doi.org/10.1117/12.2256302

KEYWORDS: Infrared radiation, Neurons, Brain, Nervous system, Modulation, Luminescence, Laser ablation, Laser cutting, Tissues, Electrodes

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Proceedings Article | 28 February 2017 Presentation + Paper

Reducing peak temperatures during infrared inhibition of neural potentials

Jeremy Ford, Michael Jenkins, Hillel Chiel, E. Duco Jansen

Proceedings Volume 10052, 100520B (2017) https://doi.org/10.1117/12.2250019

KEYWORDS: Nerve, Infrared radiation, Optical fibers, Computational modeling, Tissues, Electrodes, Temperature metrology, Action potentials, Tissue optics, Fiber lasers

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Proceedings Article | 26 April 2016 Presentation

Selective control of small versus large diameter axons using infrared laser light (Conference Presentation)

Emilie Lothet, Kendrick Shaw, Charles Horn, Hui Lu, Yves Wang, E. Duco Jansen, Hillel Chiel, Michael Jenkins

Proceedings Volume 9690, 96901N (2016) https://doi.org/10.1117/12.2212945

KEYWORDS: Axons, Optical fibers, Neurons, Infrared lasers, Infrared radiation, Sensors, Nervous system, Mathematics, Ocean optics, Nerve

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Proceedings Article | 9 March 2016 Presentation + Paper

Modeling the effects of elevated temperatures on action potential propagation in unmyelinated axons

Mohit Ganguly, Michael Jenkins, Hillel Chiel, E. Duco Jansen

Proceedings Volume 9690, 96901O (2016) https://doi.org/10.1117/12.2211048

KEYWORDS: Axons, Nerve, Action potentials, Infrared lasers, Neurophotonics, Neurons, Ion channels, Computational modeling, Sensors, Fiber optics, Thermal modeling, Potassium, Sodium, Optical fibers

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SPIE Journal Paper | 23 February 2015 Open Access

Infrared neural stimulation of human spinal nerve roots in vivo

Jonathan Cayce, Jonathon Wells, Jonathan Malphrus, Chris Kao, Sharon Thomsen, Noel Tulipan, Peter Konrad, E. Duco Jansen, Anita Mahadevan-Jansen

NPh, Vol. 2, Issue 01, 015007, (February 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.1.015007

KEYWORDS: Nerve, Infrared radiation, Tissues, Electromyography, Safety, In vivo imaging, Optical fibers, Surgery, Diagnostics, Tissue optics

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SPIE Journal Paper | 28 July 2014 Open Access

Alternating current and infrared produce an onset-free reversible nerve block

Emilie Lothet, Kevin Kilgore, Niloy Bhadra, Narendra Bhadra, Tina Vrabec, Yves Wang, E. Duco Jansen, Michael Jenkins, Hillel Chiel

NPh, Vol. 1, Issue 01, 011010, (July 2014) https://doi.org/10.1117/12.10.1117/1.NPh.1.1.011010

KEYWORDS: Nerve, Electrodes, Infrared radiation, Ocean optics, Infrared lasers, Optical fibers, Action potentials, Axons, Pulsed laser operation, Biomedical engineering

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Proceedings Article | 18 February 2011 Paper

Nerve fiber recruitment in the context of hybrid neural stimulation

Austin Duke, Hui Lu, Michael Jenkins, Melanie Gault, Jeffrey McManus, Hillel Chiel, E. Duco Jansen

Proceedings Volume 7883, 788353 (2011) https://doi.org/10.1117/12.879951

KEYWORDS: Nerve, Optical fibers, Tissue optics, Ocean optics, Neurons, Electrodes, Infrared radiation, Optical components, Tissues, Biomedical engineering

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Proceedings Article | 12 February 2010 Paper

The effect of temperature of fluorescence: an animal study

Alex Walsh, Bart Masters, Duco Jansen, A. Welch, Anita Mahadevan-Jansen

Proceedings Volume 7562, 75620W (2010) https://doi.org/10.1117/12.842578

KEYWORDS: Luminescence, Tissues, Temperature metrology, Optical properties, Diffuse reflectance spectroscopy, Skin, Eye, Collagen, Cameras, Tissue optics

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SPIE Journal Paper | 1 November 2009 Open Access

Combined optical and electrical stimulation of neural tissue in vivo

Austin Duke, Jonathan Cayce, Jonathan Malphrus, Peter Konrad, Anita Mahadevan-Jansen, E. Duco Jansen

JBO, Vol. 14, Issue 06, 060501, (November 2009) https://doi.org/10.1117/12.10.1117/1.3257230

KEYWORDS: Tissue optics, Infrared radiation, Nerve, Ocean optics, Electrodes, Laser tissue interaction, In vivo imaging, Laser induced damage, Laser damage threshold, Semiconductor lasers

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SPIE Journal Paper | 1 September 2008 Open Access

In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin

Gerald Wilmink, Susan Opalenik, Joshua Beckham, Mark Mackanos, Lillian Nanney, Christopher Contag, Jeffrey Davidson, E. Duco Jansen

JBO, Vol. 13, Issue 05, 054066, (September 2008) https://doi.org/10.1117/12.10.1117/1.2992594

KEYWORDS: Tissues, Laser ablation, Free electron lasers, Skin, Laser tissue interaction, Optical imaging, Proteins, Green fluorescent protein, In vivo imaging, Luminescence

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Proceedings Article | 26 February 2008 Paper

Laser thermal preconditioning enhances dermal wound repair

Gerald Wilmink, Terry Carter, Jeffrey Davidson, E. Duco Jansen

Proceedings Volume 6842, 68420O (2008) https://doi.org/10.1117/12.767258

KEYWORDS: Tissues, Infrared cameras, Skin, Temperature metrology, Wound healing, In vivo imaging, Thermography, Semiconductor lasers, In vitro testing, Mouse models

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Proceedings Article | 20 February 2008 Paper

Characterization of single auditory nerve fibers in response to laser stimulation

Phillip Littlefield, Agnella Izzo, Jagmeet Mundi, Joseph Walsh, E. Duco Jansen, Mark Bendett, Jim Webb, Heather Ralph, Claus-Peter Richter

Proceedings Volume 6854, 68540F (2008) https://doi.org/10.1117/12.768129

KEYWORDS: Action potentials, Optical fibers, Neurons, Nerve, Pulsed laser operation, Acoustics, Ear, Laser damage threshold, Scanning probe lithography, Fourier transforms

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Proceedings Article | 20 February 2008 Paper

Frontiers in optical stimulation of neural tissues: past, present, and future

Jonathon Wells, Mark Bendett, Jim Webb, Claus Richter, Agnella Izzo, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 6854, 68540B (2008) https://doi.org/10.1117/12.776988

KEYWORDS: Nerve, Tissues, Tissue optics, Electrodes, Safety, Neurons, Infrared radiation, Action potentials, Nervous system, Brain

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Proceedings Article | 20 February 2008 Paper

Use of optical reporter genes to assess sublethal cellular damage following skin ablation

Gerald Wilmink, Susan Opalenik, Jeffrey Davidson, E. Duco Jansen

Proceedings Volume 6854, 685403 (2008) https://doi.org/10.1117/12.767263

KEYWORDS: Tissues, Proteins, Free electron lasers, Skin, Laser ablation, Laser tissue interaction, Green fluorescent protein, Absorption, Laser therapeutics, Tissue optics

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Proceedings Article | 12 February 2008 Paper

Validation of luminescent source reconstruction using spectrally resolved bioluminescence images

John Virostko, Alvin Powers, E. Jansen

Proceedings Volume 6849, 68490I (2008) https://doi.org/10.1117/12.771416

KEYWORDS: Bioluminescence, Tissue optics, Optical properties, Abdomen, Imaging systems, 3D applications, 3D image processing, Image analysis, Light, 3D image reconstruction

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Proceedings Article | 21 February 2007 Paper

Laser stimulation of auditory neurons at high-repetition rate

Agnella Izzo, Philip Littlefield, Joseph Walsh, Jim Webb, Heather Ralph, Mark Bendett, E. Duco Jansen, Claus-Peter Richter

Proceedings Volume 6435, 64350R (2007) https://doi.org/10.1117/12.700846

KEYWORDS: Electrodes, Pulsed laser operation, Neurons, Action potentials, Tissue optics, Nerve, Laser tissue interaction, Soft tissue optics, Mid-IR, Sensors

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Proceedings Article | 8 February 2007 Paper

Wavelength-dependent dynamics of heat shock protein 70 expression in free electron laser wounds

Gerald Wilmink, Joshua Beckham, Mark Mackanos, Christopher Contag, Jeffrey Davidson, E. Jansen

Proceedings Volume 6440, 644003 (2007) https://doi.org/10.1117/12.705085

KEYWORDS: Free electron lasers, Tissues, Laser tissue interaction, Absorption, Skin, Tissue optics, Proteins, Light scattering, Scattering, Collagen

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SPIE Journal Paper | 1 September 2006 Open Access

Use of glycerol as an optical clearing agent for enhancing photonic transference and detection of Salmonella typhimurium through porcine skin

Keesla Moulton, Frank Lovell, Ellen Williams, Peter Ryan, Donald Lay, Eric Jansen, Scott Willard

JBO, Vol. 11, Issue 05, 054027, (September 2006) https://doi.org/10.1117/12.10.1117/1.2363366

KEYWORDS: Skin, Optical clearing, Photodetectors, Tissue optics, Photons, Light scattering, Scattering, Control systems, Absorption, Transmittance

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SPIE Journal Paper | 1 July 2006 Open Access

Effect of optical tissue clearing on spatial resolution and sensitivity of bioluminescence imaging

Eric Jansen, Patrick Pickett, Mark Mackanos, Jack Virostko

JBO, Vol. 11, Issue 04, 041119, (July 2006) https://doi.org/10.1117/12.10.1117/1.2337651

KEYWORDS: Skin, In vivo imaging, Spatial resolution, Bioluminescence, Scattering, Tissue optics, Light scattering, In vitro testing, Cameras, Tissue clearing

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SPIE Journal Paper | 1 July 2006 Open Access

Assessing laser-tissue damage with bioluminescent imaging

Gerald Wilmink, Susan Opalenik, Josh Beckham, Jeffrey Davidson, Eric Jansen

JBO, Vol. 11, Issue 04, 041114, (July 2006) https://doi.org/10.1117/12.10.1117/1.2339012

KEYWORDS: Proteins, Gas lasers, Bioluminescence, Skin, Laser induced damage, Laser tissue interaction, Carbon monoxide, Tissues, Animal model studies, Microscopy

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Effective medical laser procedures are achieved by selecting laser parameters that minimize undesirable tissue damage. Traditionally, human subjects, animal models, and monolayer cell cultures have been used to study wound healing, tissue damage, and cellular effects of laser radiation. Each of these models has significant limitations, and consequently, a novel skin model is needed. To this end, a highly reproducible human skin model that enables noninvasive and longitudinal studies of gene expression was sought. In this study, we present an organotypic raft model (engineered skin) used in combination with bioluminescent imaging (BLI) techniques. The efficacy of the raft model was validated and characterized by investigating the role of heat shock protein 70 (hsp70) as a sensitive marker of thermal damage. The raft model consists of human cells incorporated into an extracellular matrix. The raft cultures were transfected with an adenovirus containing a murine hsp70 promoter driving transcription of luciferase. The model enables quantitative analysis of spatiotemporal expression of proteins using BLI. Thermal stress was induced on the raft cultures by means of a constant temperature water bath or with a carbon dioxide (CO2) laser (=10.6 µm, 0.679 to 2.262 W/cm2, cw, unfocused Gaussian beam, L=4.5 mm, 1 min exposure). The bioluminescence was monitored noninvasively with an IVIS 100 Bioluminescent Imaging System. BLI indicated that peak hsp70 expression occurs 4 to 12 h after exposure to thermal stress. A minimum irradiance of 0.679 W/cm2 activated the hsp70 response, and a higher irradiance of 2.262 W/cm2 was associated with a severe reduction in hsp70 response due to tissue ablation. Reverse transcription polymerase chain reaction demonstrated that hsp70 mRNA levels increased with prolonged heating exposures. Enzyme-linked immunosorbent protein assays confirmed that luciferase was an accurate surrogate for hsp70 intracellular protein levels. Hematoxylin and eosin stains verified the presence of the ...

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SPIE Journal Paper | 1 July 2006 Open Access

Special Section Guest Editorial: Pioneers in Biomedical Optics: Special Section Honoring Professor Ashley J. Welch, University of Texas at Austin

E. Duco Jansen, Sohi Rastegar

JBO, Vol. 11, Issue 04, 041101, (July 2006) https://doi.org/10.1117/12.10.1117/1.2244579

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Proceedings Article | 1 March 2006 Paper

Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue

Jonathon Wells, Chris Kao, Peter Konrad, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 6084, 60840X (2006) https://doi.org/10.1117/12.655239

KEYWORDS: Nerve, Laser tissue interaction, Tissue optics, Pulsed laser operation, Tissues, Temperature metrology, Alexandrite lasers, Natural surfaces, Absorption, Free electron lasers

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Background/Objective: The traditional method of stimulating neural activity has been based on electrical methods and remains the gold standard to date despite inherent limitations. We have previously shown a new paradigm to in vivo neural activation based on pulsed infrared light, which provides a contact-free, spatially selective, artifact-free method without incurring tissue damage that may have significant advantages over electrical stimulation in a variety of diagnostic and therapeutic applications. The goal of this study was to investigate the physical mechanism of this phenomenon, which we propose is a photo-thermal effect from transient tissue temperature changes resulting in direct or indirect activation of transmembrane ion channels causing propagation of the action potential. Methods: Rat sciatic nerve preparation was stimulated in vivo with the Holmium:YAG laser (2.12μm), Free Electron Laser (2.1μm), Alexandrite laser (690nm), and the prototype for a solid state commercial laser nerve stimulator built by Aculight (1.87μm) to determine contributions of photobiological responses from laser tissue interactions, including temperature, pressure, electric field, and photochemistry, underlying the biophysical mechanism of stimulation. Single point temperature measurements were made with a microthermocouple adjacent to the excitation site, while an infrared camera was used for 2-D radiometry of the irradiated surface. Displacement from laser-induced pressure waves or thermoelastic expansion was measured using a PS-OCT system. Results: Results exclude a direct photochemical, electric field, or pressure wave effect as the mechanism of optical stimulation. Measurements show relative small contributions from thermoelastic expansion (300 nm) with the laser parameters used for nerve stimulation. The maximum change in tissue temperature is about 9°C (average increase of 3.66 °C) at stimulation threshold radiant exposures. Conclusion: Neural activation with pulsed laser-light occurs by a transient thermally induced mechanism. Future experiments will reveal if this effect is through direct membrane interaction or facilitated through an indirect effect leading to membrane depolarization.

Proceedings Article | 22 February 2006 Paper

Selectivity of optical stimulation in the auditory system

Agnella Izzo, Jyoti Pathria, Eul Suh, Joseph Walsh, Donna Whitlon, E. Jansen, Claus-Peter Richter

Proceedings Volume 6078, 60781P (2006) https://doi.org/10.1117/12.659743

KEYWORDS: Tissue optics, Tissues, Optical fibers, Neurons, Acoustics, Soft tissue optics, Nerve, Electrodes, Action potentials, Pulsed laser operation

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SPIE Journal Paper | 1 November 2005 Open Access

Application of infrared light for in vivo neural stimulation

Jonathon Wells, Chris Kao, E. Duco Jansen, Peter Konrad, Anita Mahadevan-Jansen

JBO, Vol. 10, Issue 06, 064003, (November 2005) https://doi.org/10.1117/12.10.1117/1.2121772

KEYWORDS: Nerve, Tissue optics, Absorption, Laser tissue interaction, Tissues, Free electron lasers, Infrared radiation, Neurons, Safety, In vivo imaging

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Proceedings Article | 18 April 2005 Paper

Corneal ablation using the pulse stretched free electron laser

Mark Mackanos, Karen Joos, John Kozub, E. Jansen

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.596603

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Cornea, Tissues, Optical fibers, Statistical analysis, Eye, Laser sources, Absorption

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The Mark-III Free Electron Laser (FEL), tuned to λ=6.45 μm has been demonstrated to provide for efficient ablation in ocular and neural tissues with minimal collateral damage. To date, the role of the FEL pulse structure on the mechanism of ablation has not been determined. In an effort to study the role of the FEL micropulse on the ablation of corneal tissue, the native pulse structure of the FEL, a 2.85 gigahertz repetition of picosecond pulses within a five microsecond macropulse envelope, was changed using a a pulse stretcher. This device changes the duration of the micropulse from 1 picosecond to 30-200 picoseconds in length, thus reducing the peak intensity of the micropulse by as much as 200x the original intensity, while the macropulse energy remains unchanged. Two basic metrics were studied: the ablation threshold on water and the ablation crater depth on gelatin. These metrics were employed at λ=6.45 and 6.1 μm for 1, 100, and 200 picoseconds in micropulse duration. The results showed a very slight difference between the 1, 100, and 200 picosecond micropulse duration, given a 200 fold decrease in peak energy for both the threshold and crater depth measurements. Brightfield imaging was also performed to probe the ablation dynamics and showed no difference between the 1 and 200 ps micropulses. The effect of changing the micropulse duration was studied on the ablation of canine cornea. Craters (500 micron diameter) were created with 25 pulses at three times the ablation threshold as determined for water on freshly enucleated corneas within 12 hours of removal. Three rows of seven craters were created on the center of each cornea. The native one picosecond micropulse and 200 picosecond stretched micropulse were compared at λ=6.1 and 6.45 μm. Histological data shows that less thermal damage is present at 6.1 μm compared with 6.45 μm; however, there is no significant difference between the native and stretched pulses with respect to thermal damage.

Proceedings Article | 15 April 2005 Paper

Comparison of OPO and Mark-III FEL for mid-infrared soft tissue ablation

Mark Mackanos, Dmitrii Simanovski, H. Alan Schwettman, E. Duco Jansen

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.597215

KEYWORDS: Free electron lasers, Laser ablation, Optical parametric oscillators, Pulsed laser operation, Laser sources, Tissues, Mid-IR, Laser damage threshold, Laser tissue interaction, Picosecond phenomena

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Proceedings Article | 15 April 2005 Paper

Analysis of soft tissue ablation using the pulse stretched free electron laser

Mark Mackanos, John Kozub, Darrel Ellis, E. Duco Jansen

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.596608

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Laser tissue interaction, Tissues, Skin, Pulsed laser operation, Laser sources, Statistical analysis, Ultraviolet radiation

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Proceedings Article | 1 July 2004 Paper

Effect of FEL micropulse duration on ablation characteristics at 6.45 um

Mark Mackanos, John Kozub, E. Jansen

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.535803

KEYWORDS: Picosecond phenomena, Free electron lasers, Laser ablation, Tissues, Skin, Laser tissue interaction, Optical coherence tomography, Statistical analysis, Pulsed laser operation, Error analysis

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Proceedings Article | 1 July 2004 Paper

Ablation of soft tissue at 6.45 um using a strontium vapor laser

Mark Mackanos, Borislav Ivanov, Anatoly Soldatov, I. Kostadinov, Marcus Mendenhall, David Piston, Richard Haglund, E. Jansen

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.535479

KEYWORDS: Laser ablation, Laser tissue interaction, Strontium, Free electron lasers, Strontium vapor lasers, Pulsed laser operation, Mirrors, Superposition, Laser development, Tissues

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Proceedings Article | 14 June 2004 Paper

Visualization of tumor-induced VEGF expression using in vivo bioluminescence

Shannon Faley, Cornelia Crooke, Keiko Takahashi, Takamune Takahashi, E. Duco Jansen

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.536430

KEYWORDS: Tumors, Tissues, In vivo imaging, Visualization, Wound healing, Mouse models, Luminescence, Hypoxia, Bioluminescence, Animal model studies

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Proceedings Article | 1 June 2004 Paper

Effect of micropulse duration on tissue ablation using a stretched free electron laser pulse train

John Kozub, Mark Mackanos, Marcus Mendenhall, E. Duco Jansen

Proceedings Volume 5340, (2004) https://doi.org/10.1117/12.535893

KEYWORDS: Free electron lasers, Laser ablation, Picosecond phenomena, Tissues, Laser tissue interaction, Absorption, Pulsed laser operation, Spectroscopy, Skin, Optical coherence tomography

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SPIE Journal Paper | 1 October 2003 Open Access

Delivery of midinfrared (6 to 7-μm) laser radiation in a liquid environment using infrared-transmitting optical fibers

Mark Mackanos, E. Duco Jansen, Brandon Shaw, Jasbinder Sanghera, Ishwar Aggarwal, Abraham Katzir

JBO, Vol. 8, Issue 04, (October 2003) https://doi.org/10.1117/12.10.1117/1.1606460

KEYWORDS: Tissues, Liquids, Silver, Absorption, Laser ablation, Free electron lasers, Arsenic, Fiber lasers, Laser damage threshold, Laser tissue interaction

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Proceedings Article | 27 August 2003 Paper

Bioluminescence imaging as a marker for cellular Hsp70 response to thermal laser injury

Joshua Beckham, Jennifer Baran, Mark Mackanos, Cornelia Crooke, Takamune Takahashi, Caitlin O'Connell-Rodwell, Christopher Contag, E. Duco Jansen

Proceedings Volume 4961, (2003) https://doi.org/10.1117/12.502190

KEYWORDS: Proteins, Photon counting, Bioluminescence, Tissues, Cell death, Laser irradiation, Injuries, Flow cytometry, Time correlated photon counting, Pulsed laser operation

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Proceedings Article | 22 July 2003 Paper

Optical tracking of the three-dimensional position of an ablative focused laser beam

Steven Gebhart, Robert Galloway, E. Duco Jansen

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.497355

KEYWORDS: Laser ablation, Optical tracking, Laser therapeutics, Tissues, Surgery, Free electron lasers, Laser beam diagnostics, Tumors, Image-guided intervention, Error analysis

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Proceedings Article | 14 July 2003 Paper

Fiber-delivered mid-infrared (6-7 µm) laser ablation of retinal tissue under perfluorodecalin

Mark Mackanos, Karen Joos, E. Duco Jansen

Proceedings Volume 4951, (2003) https://doi.org/10.1117/12.482369

KEYWORDS: Laser ablation, Tissues, Retina, Optical fibers, Silver, Absorption, Free electron lasers, Vitreous, Eye, Laser tissue interaction

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Proceedings Article | 30 May 2003 Paper

Dynamic three-dimensional optical tracking of an ablative laser beam

Steven Gebhart, Robert Galloway, E. Duco Jansen

Proceedings Volume 5029, (2003) https://doi.org/10.1117/12.480208

KEYWORDS: Laser ablation, Laser therapeutics, Optical tracking, Tissues, Surgery, Free electron lasers, Tumors, Laser beam diagnostics, Brain, Image-guided intervention

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Proceedings Article | 13 June 2002 Paper

Acute optic nerve sheath fenestration in humans using the free electron laser (FEL): a case report

Karen Joos, Louise Mawn, Jin-Hui Shen, E. Duco Jansen, Vivien Casagrande

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470579

KEYWORDS: Optic nerve, Free electron lasers, Surgery, Hollow waveguides, Nerve, Tissues, Medical research, Waveguides, Analytical research, Eye

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Proceedings Article | 9 July 2001 Paper

Effects of IR wavelength on ablation mechanics: a study of acoustic signals

Stephen Uhlhorn, David Mongin, Mark Mackanos, E. Duco Jansen

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434702

KEYWORDS: Acoustics, Laser ablation, Free electron lasers, Absorption, Proteins, Laser tissue interaction, Tissues, Infrared lasers, Laser energy, Mechanics

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Proceedings Article | 9 July 2001 Paper

Optical imaging of Hsp70 gene expression following thermal laser injury

Josh Beckham, J. Baran, A. Izzo, E. Duco Jansen

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434723

KEYWORDS: Proteins, Laser irradiation, Pulsed laser operation, Injuries, Temperature metrology, Laser tissue interaction, Photon counting, Cameras, Absorption, Bioluminescence

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Proceedings Article | 2 July 2001 Paper

Brain tissue charcterization using spectral imaging: a potential clinical tool

Anita Mahadevan-Jansen, David Mongin, E. Duco Jansen, Dawn Pedrotty, Wei-Chiang Lin

Proceedings Volume 4259, (2001) https://doi.org/10.1117/12.432484

KEYWORDS: Brain, Tissues, Imaging spectroscopy, Tumors, Luminescence, Neuroimaging, Imaging systems, Tissue optics, Data acquisition, Optical spectroscopy

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Proceedings Article | 4 June 2001 Paper

Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra

Wei-Chiang Lin, Anita Mahadevan-Jansen, E. Duco Jansen

Proceedings Volume 4254, (2001) https://doi.org/10.1117/12.427932

KEYWORDS: Blood, Tissue optics, Luminescence, Contamination, Tumors, Brain, Diffuse reflectance spectroscopy, Tissues, Monte Carlo methods, Optical spectroscopy

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Proceedings Article | 13 June 2000 Paper

Hydrodynamic modeling of tissue ablation with a free-electron laser

Stephen Uhlhorn, Richard London, Anthony Makarewicz, E. Duco Jansen

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388050

KEYWORDS: Free electron lasers, Picosecond phenomena, Tissues, Laser ablation, Laser tissue interaction, Pulsed laser operation, Absorption, Tunable lasers, Wave propagation, Laser systems engineering

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Proceedings Article | 3 May 2000 Paper

Spectroscopic-guided brain tumor resection

Wei-Chiang Lin, Steven Toms, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 3911, (2000) https://doi.org/10.1117/12.384896

KEYWORDS: Tumors, Brain, Tissues, Electroluminescence, Luminescence, Diffuse reflectance spectroscopy, Spectroscopy, In vivo imaging, Optical spectroscopy, Algorithm development

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Proceedings Article | 28 April 2000 Paper

Influence of optical absorption on urinary calculus threshold fluence and ablation efficiency during infrared laser ablation

Kin Foong Chan, Daniel Hammer, Bernard Choi, Gracie Vargas, Brian Sorg, T. Joshua Pfefer, Joel Teichman, H. Stan McGuff, Hans Pratisto, E. Duco Jansen, Ashley Welch

Proceedings Volume 3925, (2000) https://doi.org/10.1117/12.384253

KEYWORDS: Laser ablation, Absorption, Calculi, Laser damage threshold, Tissue optics, Calculus, Absorbance, Hard tissue optics, Free electron lasers, Infrared radiation

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Proceedings Article | 28 April 2000 Paper

Free-electron laser tissue-soldering in vitro with an albumin solder

Brian Sorg, Bernard Choi, Karen McNally-Heintzelman, E. Duco Jansen, Ashley Welch

Proceedings Volume 3925, (2000) https://doi.org/10.1117/12.384257

KEYWORDS: Absorption, Free electron lasers, Laser welding, Laser tissue interaction, Tissues, Chromophores, Natural surfaces, In vitro testing, Infrared radiation, Proteins

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SPIE Journal Paper | 1 April 2000 Open Access

Brain tumor demarcation using optical spectroscopy: an in vitro study

Wei-Chiang Lin, Steven Toms, Massoud Motamedi, E. Duco Jansen, Anita Mahadevan-Jansen

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429989

KEYWORDS: Brain, Tumors, Tissues, Luminescence, Diffuse reflectance spectroscopy, Algorithm development, In vitro testing, Reflectivity, Optical spectroscopy, Spectroscopy

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Proceedings Article | 14 June 1999 Paper

Tissue ablation with the free-electron laser: contributions of wavelength and pulse structure

Stephen Uhlhorn, Shannon Harrison, Hans Pratisto, E. Duco Jansen

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350020

KEYWORDS: Laser ablation, Laser tissue interaction, Free electron lasers, Tissues, Pulsed laser operation, Absorption, Picosecond phenomena, Birefringence, Heart, Proteins

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Proceedings Article | 21 April 1999 Paper

Clinical beam delivery of the Vanderbilt FEL: design and performance of a hollow-waveguide-based handheld probe for neurosurgery

Hans Pratisto, Stephen Uhlhorn, Michael Copeland, E. Duco Jansen

Proceedings Volume 3596, (1999) https://doi.org/10.1117/12.346727

KEYWORDS: Free electron lasers, Hollow waveguides, Picosecond phenomena, Nitrogen, Absorption, Wave propagation, Waveguides, Optical testing, Beam propagation method, Beam delivery

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Proceedings Article | 13 May 1998 Paper

Fluorescence-based temperature measurement in laser-induced vapor bubbles

Kin Foong Chan, T. Joshua Pfefer, Daniel Hammer, E. Duco Jansen, Martin Frenz, Ashley Welch

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308174

KEYWORDS: Temperature metrology, Pulsed laser operation, Luminescence, Fiber lasers, Optical fibers, Infrared radiation, Photography, Spatial resolution, Spherical lenses, Laser irradiation

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Proceedings Article | 17 May 1996 Paper

Laser-tissue interaction during transmyocardial laser revascularization

E. Duco Jansen, Martin Frenz, Kamuran Kadipasaoglu, T. Joshua Pfefer, Hans Altermatt, Massoud Motamedi, Ashley Welch

Proceedings Volume 2671, (1996) https://doi.org/10.1117/12.239990

KEYWORDS: Laser tissue interaction, Pulsed laser operation, Tissues, Liquids, Laser ablation, Heart, Laser drilling, Photography, Tissue optics, Natural surfaces

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Proceedings Article | 7 May 1996 Paper

Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation

Martin Frenz, Hans Pratisto, Cynthia Toth, E. Duco Jansen, Hans Altermatt, Ashley Welch, Heinz Weber

Proceedings Volume 2681, (1996) https://doi.org/10.1117/12.239593

KEYWORDS: Liquids, Laser ablation, Laser tissue interaction, Erbium lasers, Tissues, Holmium, Pulsed laser operation, Absorption, Picosecond phenomena, Er:YAG lasers

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Proceedings Article | 7 May 1996 Paper

Shock wave and cavitation bubble measurements of ultrashort-pulse laser-induced breakdown in water

Daniel Hammer, Robert Thomas, Martin Frenz, E. Duco Jansen, Gary Noojin, Sarah Diggs, Joachim Noack, Alfred Vogel, Benjamin Rockwell

Proceedings Volume 2681, (1996) https://doi.org/10.1117/12.239605

KEYWORDS: Cavitation, Picosecond phenomena, Plasma, Pulsed laser operation, Spatial filters, Laser energy, Laser induced damage, Sensors, Spherical lenses, Ultrafast phenomena

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Proceedings Article | 22 May 1995 Paper

Effect of Young's modulus on bubble formation and pressure waves during pulsed holmium ablation of tissue phantoms

E. Duco Jansen, Thomas Asshauer, Martin Frenz, Guy Delacretaz, Massoud Motamedi, Ashley Welch

Proceedings Volume 2391, (1995) https://doi.org/10.1117/12.209906

KEYWORDS: Pulsed laser operation, Tissues, Laser ablation, Q switched lasers, Q switching, Fiber lasers, Laser tissue interaction, Holmium, Photography, Tissue optics

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Proceedings Article | 12 May 1995 Paper

Reduction of excimer laser-induced vapor bubble size in blood: saline flush and pulse multiplexing

Ton van Leeuwen, E. Duco Jansen, Ashley Welch, Cornelius Borst

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.628064

Proceedings Article | 12 May 1995 Paper

Effect of pulse duration on photomechanical response of soft tissue during Ho:YAG laser ablation

E. Duco Jansen, Massoud Motamedi, T. Joshua Pfefer, Thomas Asshauer, Martin Frenz, Guy Delacretaz, George Abela, Ashley Welch

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209071

KEYWORDS: Pulsed laser operation, Laser tissue interaction, Laser ablation, Tissues, Fiber lasers, Q switched lasers, Holmium, Q switching, Photography, Picosecond phenomena

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Mechanical injury during pulsed holmium laser ablation of tissue is caused by rapid bubble expansion and collapse or by laser-induced pressure waves. In this study the effect of pulse duration on the photomechanical response of soft tissue during holmium:YAG laser ablation has been investigated. The dynamics of laser-induced bubble formation was documented in water and in transparent polyacrylamide tissue phantoms with a water concentration of 84%. Holmium:YAG laser radiation ((lambda) equals 2.12 micrometers ) was delivered in water or tissue phantoms via an optical fiber (200 or 400 micrometers ). The laser was operated in either the Q- switched mode ((tau) _p equals 500 ns, Q_p equals 14 +/- 1 mJ, 200 micrometers fiber, H_o equals 446 mJ/mm²) or the free-running mode ((tau) _p equals 100 - 1100 microsecond(s) , Q_p equals 200 +/- 5 mJ, 400 micrometers fiber, H_o equals 1592 mJ/mm²). Bubble formation was documented using a fast flash photography setup while simultaneously a PVDP needle hydrophone (40 ns risetime), recorded pressures. The effect of the pulse duration on the photomechanical response of soft biological tissue was evaluated by delivering 5 pulses of 800 mJ to the intimal side of porcine aorta in vitro, followed by histologic evaluation. It was observed that, as the pulse duration was increased the bubble shape changed from almost spherical for Q-switched pulses to a more elongated, cylindrical shape for the longer pulse durations. The bubble expansion velocity was larger for shorter pulse durations. A thermo- elastic expansion wave was measured only during Q-switched pulse delivery. All pulses that induced bubble formation generated pressure waves upon collapse of the bubble in water as well as in the gel. The amplitude of the pressure wave depended strongly on the size and geometry of the laser-induced bubble. The important findings of this study were (1) the magnitude of collapse pressure wave decreased as laser pulse duration increased, and (2) mechanical tissue damage is reduced significantly by using longer pulse durations (> 460 microsecond(s) , for the pulse energy used).

Proceedings Article | 18 January 1995 Paper

Acoustic transients in pulsed holmium laser ablation: effects of pulse duration

Thomas Asshauer, Guy Delacretaz, E. Duco Jansen, Ashley Welch, Martin Frenz

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199189

KEYWORDS: Pulsed laser operation, Acoustics, Holmium, Cavitation, Tissues, Q switched lasers, Q switching, Picosecond phenomena, Laser ablation, Fiber lasers

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Proceedings Article | 1 February 1994 Paper

Effect of temperature on the absorption coefficient of water for Ho:YAG laser light

E. Duco Jansen, Ton van Leeuwen, Massoud Motamedi, Cornelius Borst, Ashley Welch

Proceedings Volume 2077, (1994) https://doi.org/10.1117/12.168029

KEYWORDS: Absorption, Temperature metrology, Water, Spectrophotometry, Pulsed laser operation, Optical properties, Laser tissue interaction, Laser ablation, Laser scattering, Tissues

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Proceedings Article | 7 July 1993 Paper

Bubble formation during pulsed laser ablation: mechanism and implications

Ton van Leeuwen, E. Duco Jansen, Massoud Motamedi, Ashley Welch, Cornelius Borst

Proceedings Volume 1882, (1993) https://doi.org/10.1117/12.147658

KEYWORDS: Excimer lasers, Laser tissue interaction, Holmium, Laser damage threshold, Pulsed laser operation, Laser ablation, Excimers, Blood, Absorption, Picosecond phenomena

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Proceedings Article | 7 July 1993 Paper

Influence of tissue mechanical strength during UV and IR laser ablation in vitro

E. Duco Jansen, Ton van Leeuwen, Rudolf Verdaasdonck, Tuong Le, Massoud Motamedi, Ashley Welch, Cornelius Borst

Proceedings Volume 1882, (1993) https://doi.org/10.1117/12.147654

KEYWORDS: Tissues, Laser ablation, Laser tissue interaction, Pulsed laser operation, Excimer lasers, Holmium, Liver, Cartilage, Bone, Cornea

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Proceedings Article | 7 July 1993 Paper

Pulsed infrared laser irradiation of biological tissue: effect of pulse duration and repetition rate

E. Duco Jansen, Ravi Chundru, Salim Samanani, Todd Tibbetts, Ashley Welch

Proceedings Volume 1882, (1993) https://doi.org/10.1117/12.147672

KEYWORDS: Pulsed laser operation, Laser tissue interaction, Laser ablation, Cameras, Temperature metrology, Continuous wave operation, Breast, Thermography, Thermal modeling, Diffusion

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Proceedings Article | 1 June 1991 Paper

In-vitro study of the effects of Congo Red on the ablation of atherosclerotic plaque

Hugo Beyerbacht, Shanti Aggarwal, E. Duco Jansen, Ashley Welch

Proceedings Volume 1427, (1991) https://doi.org/10.1117/12.44095

KEYWORDS: Laser ablation, Tissues, Laser tissue interaction, Chromophores, Laser damage threshold, Argon ion lasers, In vitro testing, Tissue optics, Absorption, Laser therapeutics

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Proceedings Article | 1 July 1990 Paper

Optically modified fiber tips penetrate only when "dirty"

Rudolf Verdaasdonck, E. Duco Jansen, F. Holstege, Cornelius Borst

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17527

KEYWORDS: Tissues, Tissue optics, Sapphire, Plasma, Natural surfaces, Absorption, Laser tissue interaction, Temperature metrology, Laser beam diagnostics, Nd:YAG lasers

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Showing 5 of 86 publications

Proceedings Volume Editor (22)

SPIE Conference Volume | 4 March 2020

Optogenetics and Optical Manipulation 2020

SPIE Conference Volume | 2 April 2019

Optogenetics and Optical Manipulation 2019

SPIE Conference Volume | 14 May 2018

Optical Interactions with Tissue and Cells XXIX

SPIE Conference Volume | 11 May 2018

Optogenetics and Optical Manipulation 2018

SPIE Conference Volume | 28 April 2017

Optogenetics and Optical Manipulation

Showing 5 of 22 publications

Conference Committee Involvement (36)

Optogenetics and Optical Manipulation 2025

27 January 2025 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2024

27 January 2024 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2023

28 January 2023 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2022

22 January 2022 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2021

6 March 2021 | Online Only, California, United States

Optogenetics and Optical Manipulation 2020

1 February 2020 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXX

2 February 2019 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2019

2 February 2019 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXIX

29 January 2018 | San Francisco, California, United States

Optogenetics and Optical Manipulation 2018

27 January 2018 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXVIII

30 January 2017 | San Francisco, California, United States

Optogenetics and Optical Manipulation

28 January 2017 | San Francisco, California, United States

Neural Imaging and Sensing

15 February 2016 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXVII

14 February 2016 | San Francisco, California, United States

Neurophotonics

9 February 2015 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXVI

8 February 2015 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXV

3 February 2014 | San Francisco, California, United States

Neurophotonics

3 February 2014 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXIV

5 February 2013 | San Francisco, California, United States

Neurophotonics

4 February 2013 | San Francisco, California, United States

1st International Biophotonics Meeting in Israel

9 December 2012 | Tel Aviv, Israel

Optical Interactions with Tissue and Cells XXIII

23 January 2012 | San Francisco, California, United States

Photons and Neurons IV

23 January 2012 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXII

24 January 2011 | San Francisco, California, United States

Photons and Neurons III

24 January 2011 | San Francisco, California, United States

Optical Interactions with Tissues and Cells XXI

25 January 2010 | San Francisco, California, United States

Photons and Neurons II

25 January 2010 | San Francisco, California, United States

Therapeutic Laser Applications and Laser-Tissue Interactions

17 June 2009 | Munich, Germany

Optical Interactions with Tissue and Cells XX

26 January 2009 | San Jose, California, United States

Photons and Neurons

26 January 2009 | San Jose, California, United States

Optical Interactions with Tissue and Cells XIX

21 January 2008 | San Jose, California, United States

Optical Interactions with Tissue and Cells XVIII

21 January 2007 | San Jose, California, United States

Optical Interactions with Tissue and Cells XVII

23 January 2006 | San Jose, California, United States

Optical Interactions with Tissue and Cells XVI

24 January 2005 | San Jose, CA, United States

Laser Interaction with Tissue and Cells XV

26 January 2004 | San Jose, CA, United States

Laser Tissue Interaction XIV: Photochemical, Photothermal, Photomechanical

28 January 2003 | San Jose, CA, United States

Showing 5 of 36 Conference Committees

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