Prof. Jonathan T.C. Liu Profile

Prof. Jonathan T.C. Liu

Professor at Univ of Washington

SPIE Involvement:

Conference Program Committee | Editorial Board Member: Journal of Biomedical Optics | Author | Special Event Speaker

Area of Expertise:

Microendoscopy / endomicroscopy , Light-sheet microscopy , Image-guided interventions , Molecular imaging , 3D pathology , Machine learning image analysis

Websites:

Personal Website | Company Website

Profile Summary

Jonathan Liu received degrees in mechanical engineering at Princeton (B.S.E., 1999) and Stanford (M.S., 2000 & Ph.D., 2005). He was a postdoctoral fellow in the department of electrical engineering (Ginzton Labs) and the Molecular Imaging Program at Stanford (2005-2009), and was later appointed as an instructor within the Stanford University School of Medicine (2009-2010). Jonathan is currently a professor in the mechanical engineering department at the University of Washington in Seattle, with an adjunct appointment in the department of bioengineering, and of laboratory medicine & pathology. His laboratory for molecular biophotonics develops optical strategies for improving the diagnosis, grading, and treatment of diseases. Jonathan is also a co-founder and board member of Lightspeed Microscopy Inc.

Publications (40)

Proceedings Article | 13 March 2024 Poster

Poster

A comprehensive workflow to generate 3D pathology datasets for large-scale clinical studies

Kevin Bishop, Lindsey Erion Barner, Qinghua Han, Elena Baraznenok, Lydia Lan, Gan Gao, Robert Serafin, Sarah S. Chow, Jonathan T. Liu

Proceedings Volume PC12827, PC128270T (2024) https://doi.org/10.1117/12.3003339

KEYWORDS: Pathology, Tissues, Biological research, Quality control, Prostate cancer, Nondestructive evaluation, Image processing, Gold, Diseases and disorders, Decision making

Read Abstract +

SPIE Journal Paper | 1 March 2024 Open Access

Open Access

Direct three-dimensional segmentation of prostate glands with nnU-Net

Rui Wang, Sarah S. Chow, Robert Serafin, Weisi Xie, Qinghua Han, Elena Baraznenok, Lydia Lan, Kevin Bishop, Jonathan T. Liu

JBO, Vol. 29, Issue 03, 036001, (March 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.3.036001

KEYWORDS: Image segmentation, 3D modeling, Education and training, 3D image processing, Prostate, Data modeling, Biopsy, Pathology, Prostate cancer, Performance modeling

Read Abstract +

SignificanceIn recent years, we and others have developed non-destructive methods to obtain three-dimensional (3D) pathology datasets of clinical biopsies and surgical specimens. For prostate cancer risk stratification (prognostication), standard-of-care Gleason grading is based on examining the morphology of prostate glands in thin 2D sections. This motivates us to perform 3D segmentation of prostate glands in our 3D pathology datasets for the purposes of computational analysis of 3D glandular features that could offer improved prognostic performance.AimTo facilitate prostate cancer risk assessment, we developed a computationally efficient and accurate deep learning model for 3D gland segmentation based on open-top light-sheet microscopy datasets of human prostate biopsies stained with a fluorescent analog of hematoxylin and eosin (H&E).ApproachFor 3D gland segmentation based on our H&E-analog 3D pathology datasets, we previously developed a hybrid deep learning and computer vision-based pipeline, called image translation-assisted segmentation in 3D (ITAS3D), which required a complex two-stage procedure and tedious manual optimization of parameters. To simplify this procedure, we use the 3D gland-segmentation masks previously generated by ITAS3D as training datasets for a direct end-to-end deep learning-based segmentation model, nnU-Net. The inputs to this model are 3D pathology datasets of prostate biopsies rapidly stained with an inexpensive fluorescent analog of H&E and the outputs are 3D semantic segmentation masks of the gland epithelium, gland lumen, and surrounding stromal compartments within the tissue.ResultsnnU-Net demonstrates remarkable accuracy in 3D gland segmentations even with limited training data. Moreover, compared with the previous ITAS3D pipeline, nnU-Net operation is simpler and faster, and it can maintain good accuracy even with lower-resolution inputs.ConclusionsOur trained DL-based 3D segmentation model will facilitate future studies to demonstrate the value of computational 3D pathology for guiding critical treatment decisions for patients with prostate cancer.

Proceedings Article | 17 March 2023 Presentation

Presentation

Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype

Kevin Bishop, Bingwen Hu, Adam Glaser, Nader Sanai, Jonathan T. Liu

Proceedings Volume PC12356, PC1235607 (2023) https://doi.org/10.1117/12.2647997

KEYWORDS: Confocal microscopy, Surgery, Prototyping, Signal detection, In vivo imaging, Tumors, Luminescence, Tissues, Microscopy, Microscopes

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Proceedings Article | 17 March 2023 Presentation

Presentation

Comprehensive histology of fresh tumor-resection margins with rapid open-top light-sheet (OTLS) microscopy

Gan Gao, Dominie Miyasato, Lindsey Barner, Lawrence True, Jeffrey Houlton, Jonathan T. Liu

Proceedings Volume PC12363, PC123630E (2023) https://doi.org/10.1117/12.2650687

KEYWORDS: Tumors, Microscopy, Tissues, Natural surfaces, Image quality, Cancer, Visualization, Visual analytics, Real time image processing, Oncology

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Proceedings Article | 17 March 2023 Presentation

Presentation

Enhanced detection of neoplasia in esophageal biopsies via non-destructive 3D pathology with deep-learning triage

Lindsey Barner, Gan Gao, Deepti Reddi, Lydia Lan, Wynn Burke, William Grady, Jonathan T. Liu

Proceedings Volume PC12363, PC1236302 (2023) https://doi.org/10.1117/12.2657485

KEYWORDS: Pathology, Biopsy, Nondestructive evaluation, Surveillance, Esophagus, Endoscopy, 3D modeling, Visualization, Video surveillance, Tumor growth modeling

Read Abstract +

Proceedings Article | 16 March 2023 Presentation

Presentation

Non-destructive 3D pathology and analysis for oncology (Conference Presentation)

Jonathan T. Liu

Proceedings Volume PC12390, PC123900A (2023) https://doi.org/10.1117/12.2657218

KEYWORDS: Pathology, Nondestructive evaluation, Microscopy, Medicine, Genomics, Biopsy, 3D image processing

Read Abstract +

Proceedings Article | 15 March 2023 Presentation

Presentation

3D pathology of cleared clinical specimens using an optimized nonorthogonal dual-objective (NODO) open-top light-sheet (OTLS) microscope (Conference Presentation)

Kevin Bishop, Adam Glaser, Lindsey Barner, Robert Serafin, Jonathan T. Liu

Proceedings Volume PC12385, PC1238504 (2023) https://doi.org/10.1117/12.2648611

KEYWORDS: Pathology, Microscopes, Imaging systems, Microscopy, Tissues, Tissue optics, Sodium, Image resolution, Image quality, 3D image processing

Read Abstract +

Proceedings Article | 15 March 2023 Presentation

Presentation

Analysis of 3D nuclear spatial architecture for prostate cancer risk stratification (Conference Presentation)

Robert Serafin, Vanessa Roybal, Can Koyuncu, Weisi Xie, Jonathan T. Liu

Proceedings Volume PC12385, PC123850A (2023) https://doi.org/10.1117/12.2649164

KEYWORDS: Prostate cancer, Image segmentation, Prostate, Microscopy, Tissues, Nondestructive evaluation, Feature extraction, Biopsy, 3D microstructuring, 3D image processing

Read Abstract +

SPIE Journal Paper | 27 April 2022 Open Access

Open Access

In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment

Kevin Bishop, Kristen Maitland, Milind Rajadhyaksha, Jonathan T. C. Liu

JBO, Vol. 27, Issue 04, 040601, (April 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.4.040601

KEYWORDS: Tissues, Microscopy, In vivo imaging, Artificial intelligence, Biopsy, Confocal microscopy, Skin, Pathology, Image quality, Microscopes

Read Abstract +

SPIE Journal Paper | 21 March 2022 Open Access

Open Access

Multiresolution nondestructive 3D pathology of whole lymph nodes for breast cancer staging

Lindsey Barner, Adam Glaser, Chenyi Mao, Etsuo Susaki, Joshua Vaughan, Suzanne Dintzis, Jonathan T. Liu

JBO, Vol. 27, Issue 03, 036501, (March 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.3.036501

KEYWORDS: Pathology, 3D image processing, Tissues, Breast cancer, Visualization, Nondestructive evaluation, Lymphatic system, Image resolution, Microscopy, Tumors

Read Abstract +

Proceedings Article | 5 March 2021 Poster + Presentation

Poster + Presentation

Non-orthogonal dual-objective light-sheet microscopy for subcellular imaging of cleared tissues

Kevin Bishop, Robert Serafin, Philip Nicovich, Adam Glaser, Jonathan T. Liu

Proceedings Volume 11649, 1164918 (2021) https://doi.org/10.1117/12.2578762

KEYWORDS: Tissues, Microscopy, Imaging systems, Tissue optics, Systems modeling, Organisms, Microscopes, Image resolution, Confocal microscopy, Biomedical optics

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Single- and dual-objective light-sheet microscope architectures for cleared tissues: a simulation-based performance comparison

Kevin Bishop, Adam Glaser, Jonathan T. Liu

Proceedings Volume 11649, 116490R (2021) https://doi.org/10.1117/12.2577326

KEYWORDS: Computer architecture, Microscopes, Tissues, Device simulation, Tissue optics, Sodium, Point spread functions, Objectives, Microscopy, Biology

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Annotation-free 3D segmentation of prostate glands enabled with deep-learning image translation

Weisi Xie, Adam Glaser, Nicholas Reder, Nadia Postupna, Chenyi Mao, Can Koyuncu, Patrick Leo, Robert Serafin, Hongyi Huang, Anant Madabhushi, Lawrence True, Jonathan T. Liu

Proceedings Volume 11631, 116310M (2021) https://doi.org/10.1117/12.2576965

KEYWORDS: Image segmentation, Prostate, 3D image processing, 3D modeling, Tumor growth modeling, Tissues, Prostate cancer, Visualization, Microscopy, Image processing

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Method development and feasibility assessment for diagnosing 12 prostate needle cores within an hour of biopsy

Weisi Xie, Adam Glaser, Funda Vakar-Lopez, Nicholas Reder, Lawrence True, Jonathan T. Liu

Proceedings Volume 11619, 1161903 (2021) https://doi.org/10.1117/12.2576959

KEYWORDS: Biopsy, Prostate, Tissues, Pathology, Optical clearing, Nondestructive evaluation, Microscopy, Image quality standards, Image quality, Gold

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Hybrid open-top light-sheet microscopy for 3D imaging of cleared tissues with mesoscopic and sub-micron resolution

Adam Glaser, Jonathan Liu

Proceedings Volume 11649, 116490O (2021) https://doi.org/10.1117/12.2577711

KEYWORDS: Imaging systems, Tissues, Microscopes, Image resolution, Tissue optics, Spatial resolution, Objectives, Microscopy, Lenses, Range imaging

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Intensity leveling and false coloring of fluorescence-based 3D histology with FalseColor-Python

Robert Serafin, Weisi Xie, Adam Glaser, Jonathan T. Liu

Proceedings Volume 11631, 116310K (2021) https://doi.org/10.1117/12.2578572

KEYWORDS: Pathology, Microscopy, Luminescence, 3D image processing, Tissues, Standards development, Nondestructive evaluation, Diagnostics, Data processing, 3D imaging standards

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Presentation

Solid immersion meniscus lens (SIMlens) enables multi-resolution open-top light-sheet microscopy

Lindsey Barner, Adam Glaser, Hongyi Huang, Jonathan T. Liu

Proceedings Volume 11649, 116490K (2021) https://doi.org/10.1117/12.2576560

KEYWORDS: Microscopy, Solids, Pathology, Microscopes, Stereoscopy, Spherical lenses, Scanners, Range imaging, Objectives, Nondestructive evaluation

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SPIE Journal Paper | 15 December 2020 Open Access

Open Access

Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy

Weisi Xie, Adam Glaser, Funda Vakar-Lopez, Jonathan Wright, Nicholas Reder, Jonathan T. Liu, Lawrence True

JBO, Vol. 25, Issue 12, 126502, (December 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.12.126502

KEYWORDS: Biopsy, Diagnostics, Prostate, Tissues, Cancer, 3D image processing, Image processing, Microscopy, Pathology, Prostate cancer

Read Abstract +

Proceedings Article | 16 March 2020 Presentation + Paper

Presentation + Paper

Three-dimensional histo-morphometric features from light sheet microscopy images result in improved discrimination of benign from malignant glands in prostate cancer

Can Koyuncu, Andrew Janowczyk, Cheng Lu, Patrick Leo, Mehdi Alilou, Adam Glaser, Nicholas Reder, Jonathan T. Liu, Anant Madabhushi

Proceedings Volume 11320, 113200G (2020) https://doi.org/10.1117/12.2549726

KEYWORDS: Image segmentation, 3D image processing, Prostate cancer, Biopsy, Cancer, Microscopy, Pathology, Feature extraction, Tissues, Natural surfaces

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

Presentation

Next generation clinical applications of open-top light-sheet microscopy (Conference Presentation)

Adam Glaser, Nicholas Reder, Lawrence True, Jonathan T. Liu

Proceedings Volume 11216, 112160C (2020) https://doi.org/10.1117/12.2549686

KEYWORDS: Microscopy, Optical clearing, Tissues, Microscopes

Read Abstract +

Proceedings Article | 17 February 2020 Presentation + Paper

Presentation + Paper

Multi-immersion open-top light-sheet microscopy

Adam Glaser, Jonathan T. Liu

Proceedings Volume 11245, 112450I (2020) https://doi.org/10.1117/12.2543116

KEYWORDS: Microscopy, Objectives, Microscopes, Imaging systems, Tissues, Luminescence, Prostate, Mechanical engineering, Point spread functions, Refractive index

Read Abstract +

SPIE Journal Paper | 27 March 2019 Open Access

Open Access

Label-free in vivo pathology of human epithelia with a high-speed handheld dual-axis confocal microscope

Chengbo Yin, Linpeng Wei, Sanjee Abeytunge, Gary Peterson, Milind Rajadhyaksha, Jonathan T. Liu

JBO, Vol. 24, Issue 03, 030501, (March 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.3.030501

KEYWORDS: Microscopes, Confocal microscopy, Tissues, Tissue optics, Mirrors, In vivo imaging, Video, Microelectromechanical systems, Skin, Sensors

Read Abstract +

SPIE Journal Paper | 8 February 2019 Open Access

Open Access

Microscopy with ultraviolet surface excitation for wide-area pathology of breast surgical margins

Weisi Xie, Ye Chen, Yu Wang, Linpeng Wei, Chengbo Yin, Adam Glaser, Mark Fauver, Eric Seibel, Suzanne Dintzis, Joshua Vaughan, Nicholas Reder, Jonathan T. Liu

JBO, Vol. 24, Issue 02, 026501, (February 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.026501

KEYWORDS: Tissues, Natural surfaces, Point spread functions, Breast, Microscopy, Ultraviolet radiation, Image quality, Deconvolution, Pathology, Tissue optics

Read Abstract +

SPIE Journal Paper | 16 April 2018 Open Access

Open Access

High-speed Raman-encoded molecular imaging of freshly excised tissue surfaces with topically applied SERRS nanoparticles

Yu Wang, Qian Yang, Soyoung Kang, Matthew Wall, Jonathan T. Liu

JBO, Vol. 23, Issue 04, 046005, (April 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.4.046005

KEYWORDS: Nanoparticles, Tissues, Molecular imaging, Tumors, Natural surfaces, Imaging systems, Raman spectroscopy, Flow cytometry, Surface enhanced Raman spectroscopy, Spatial resolution

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Proceedings Article | 1 March 2018 Presentation + Paper

Presentation + Paper

Thick tissue diffusion model with binding to optimize topical staining in fluorescence breast cancer margin imaging

Xiaochun Xu, Soyoung Kang, Eric Navarro-Comes, Yu Wang, Jonathan T. Liu, Kenneth Tichauer

Proceedings Volume 10478, 104780N (2018) https://doi.org/10.1117/12.2286538

KEYWORDS: Tissues, Diffusion, Tumors, Data modeling, Natural surfaces, Affine motion model, Tumor growth modeling, Mathematical modeling, Luminescence, Surgery

Read Abstract +

Proceedings Article | 19 April 2017 Presentation

Presentation

A handheld MEMS-based line-scanned dual-axis confocal microscope for early cancer detection and surgical guidance (Conference Presentation)

Ye Chen, Chengbo Yin, Linpeng Wei, Adam Glaser, Sanjee Abeytunge, Gary Peterson, Michael Mandella, Nader Sanai, Milind Rajadhyaksha, Jonathan Liu

Proceedings Volume 10040, 100400W (2017) https://doi.org/10.1117/12.2250440

KEYWORDS: Tumors, Photons, Mirrors, Microscopes, Confocal microscopy, In vivo imaging, Cancer, Point-of-care devices, Pathology, Tissues

Read Abstract +

SPIE Journal Paper | 13 April 2017 Open Access

Open Access

Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology

Linpeng Wei, Ye Chen, Chengbo Yin, Sabine Borwege, Nader Sanai, Jonathan T. Liu

JBO, Vol. 22, Issue 04, 046005, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.046005

KEYWORDS: Luminescence, Microscopes, Microscopy, Tissues, Confocal microscopy, Tumors, Tissue optics, Brain, Neuroimaging, Signal detection

Read Abstract +

SPIE Journal Paper | 28 October 2015 Open Access

Open Access

Video-rate in vivo fluorescence imaging with a line-scanned dual-axis confocal microscope

Ye Chen, Danni Wang, Altaz Khan, Yu Wang, Sabine Borwege, Nader Sanai, Jonathan T. C. Liu

JBO, Vol. 20, Issue 10, 106011, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106011

KEYWORDS: In vivo imaging, Microscopes, Confocal microscopy, Luminescence, Tissues, Microscopy, Blood, Capillaries, Mirrors, Tumors

Read Abstract +

Proceedings Article | 4 March 2015 Paper

Paper

Ex-vivo tissue classification of cell surface receptor concentrations using kinetic modeling

Lagnojita Sinha, Yu Wang, Cynthia Yang, Altaz Khan, Jonathan Liu, Kenneth Tichauer

Proceedings Volume 9311, 93110S (2015) https://doi.org/10.1117/12.2077738

KEYWORDS: Tissues, Receptors, Neptunium, Californium, Tumors, Cancer, Nanoparticles, Data modeling, Natural surfaces, Raman scattering

Read Abstract +

Proceedings Article | 19 May 2014 Paper

Paper

Modulated alignment dual-axis (MAD) confocal microscopy for deep optical sectioning in tissues

Steven Leigh, Ye Chen, Jonathan Liu

Proceedings Volume 9155, 915513 (2014) https://doi.org/10.1117/12.2057734

KEYWORDS: Modulation, Tissues, Confocal microscopy, Tissue optics, Microscopy, Microscopes, Optical alignment, Monte Carlo methods, Mirrors, Light scattering

Read Abstract +

Proceedings Article | 19 May 2014 Paper

Paper

Rapid multiplexed molecular phenotyping of ex vivo and in vivo tissues with targeted SERS NPs

Yu Wang, Altaz Khan, Madhura Som, Steven Leigh, Danni Wang, Ye Chen, Patrick McVeigh, Brian Wilson, Jonathan Liu

Proceedings Volume 9155, 91550Z (2014) https://doi.org/10.1117/12.2057716

KEYWORDS: Tissues, Surface enhanced Raman spectroscopy, Multiplexing, Tumors, Raman spectroscopy, In vivo imaging, Target detection, Nanoparticles, Luminescence, Point-of-care devices

Read Abstract +

Proceedings Article | 19 May 2014 Paper

Paper

Development and optimization of a line-scanned dual-axis confocal (LS-DAC) microscope for high-speed pathology

Danni Wang, Ye Chen, Daphne Meza, Yu Wang, Jonathan Liu

Proceedings Volume 9155, 915515 (2014) https://doi.org/10.1117/12.2057743

KEYWORDS: Microscopes, Confocal microscopy, Monte Carlo methods, Gradient-index optics, Pathology, Tissues, Tissue optics, Deconvolution, Luminescence, Sensors

Read Abstract +

SPIE Journal Paper | 3 June 2013 Open Access

Open Access

Optimizing the performance of dual-axis confocal microscopes via Monte-Carlo scattering simulations and diffraction theory

Ye Chen, Jonathan Liu

JBO, Vol. 18, Issue 06, 066006, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066006

KEYWORDS: Microscopes, Monte Carlo methods, Confocal microscopy, Diffraction, Scattering, Light scattering, Tissues, Tissue optics, Spatial resolution, Sensors

Read Abstract +

SPIE Journal Paper | 2 March 2012 Open Access

Open Access

In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract

Wibool Piyawattanametha, Hyejun Ra, Kevin Loewke, Michael Mandella, Christopher Contag, Zhen Qiu, Thomas Wang, Shai Friedland, Jonathan Liu, Gordon Kino, Olav Solgaard

JBO, Vol. 17, Issue 02, 021102, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.021102

KEYWORDS: Confocal microscopy, In vivo imaging, Luminescence, Microelectromechanical systems, Tissues, Mirrors, Endoscopes, Colorectal cancer, Collimation, Scanners

Read Abstract +

SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery

Jonathan Liu, Michael Mandella, Nathan Loewke, Henry Haeberle, Hyejun Ra, Wibool Piyawattanametha, Olav Solgaard, Gordon Kino, Christopher Contag

JBO, Vol. 15, Issue 02, 026029, (March 2010) https://doi.org/10.1117/12.10.1117/1.3386055

KEYWORDS: Microscopes, Relays, Microelectromechanical systems, Mirrors, Confocal microscopy, GRIN lenses, Gradient-index optics, Actuators, Brain, Neuroimaging

Read Abstract +

Proceedings Article | 25 February 2010 Paper

Paper

Characterizing deep optical-sectioning microscopy performance with scattering phantoms and numerical simulations

Jonathan T. Liu, Michael Mandella, Gordon Kino, Christopher Contag

Proceedings Volume 7567, 756705 (2010) https://doi.org/10.1117/12.844315

KEYWORDS: Tissue optics, Scattering, Tissues, Monte Carlo methods, Confocal microscopy, Microscopes, Light scattering, Mirrors, Reflectivity, Objectives

Read Abstract +

SPIE Journal Paper | 1 May 2008 Open Access

Open Access

Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture

Jonathan Liu, Michael Mandella, James Crawford, Christopher Contag, Thomas Wang, Gordon Kino

JBO, Vol. 13, Issue 03, 034020, (May 2008) https://doi.org/10.1117/12.10.1117/1.2939428

KEYWORDS: Scattering, Mirrors, Light scattering, Confocal microscopy, Tissue optics, Monte Carlo methods, Tissues, Luminescence, Microscopes, Esophagus

Read Abstract +

Proceedings Article | 14 February 2007 Paper

Paper

Compact optical design for dual-axes confocal endoscopic microscopes

Michael Mandella, Jonathan Liu, Wibool Piyawattanametha, Hyejun Ra, Pei-Lin Hsiung, Larry Wong, Olav Solgaard, Thomas Wang, Christopher Contag, Gordon Kino

Proceedings Volume 6443, 64430E (2007) https://doi.org/10.1117/12.699484

KEYWORDS: Mirrors, Tissues, Microscopes, Microelectromechanical systems, Confocal microscopy, Natural surfaces, Endoscopy, In vivo imaging, Collimation, Scanners

Read Abstract +

SPIE Journal Paper | 1 September 2006 Open Access

Open Access

Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia

Jonathan Liu, Michael Mandella, Shai Friedland, Roy Soetikno, James Crawford, Christopher Contag, Gordon Kino, Thomas Wang

JBO, Vol. 11, Issue 05, 054019, (September 2006) https://doi.org/10.1117/12.10.1117/1.2363363

KEYWORDS: Confocal microscopy, Microscopes, Reflectivity, Gaussian beams, Image resolution, Tissue optics, Light sources, Tissues, In vivo imaging, Light scattering

Read Abstract +

Proceedings Article | 15 February 2006 Paper

Paper

A narrowband dual-axes confocal reflectance microscope for distinguishing colonic neoplasia

Jonathan Liu, Michael Mandella, Christopher Contag, Gordon Kino, Thomas Wang

Proceedings Volume 6090, 609004 (2006) https://doi.org/10.1117/12.649019

KEYWORDS: Confocal microscopy, Microscopes, Tissues, Tissue optics, Reflectivity, Image resolution, Light scattering, Light sources, Gaussian beams, Lenses

Read Abstract +

Showing 5 of 40 publications

Conference Committee Involvement (30)

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXII

29 January 2025 | San Francisco, California, United States

High-Throughput Biophotonics: Imaging, Spectroscopy, and Beyond X

25 January 2025 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications XI

25 January 2025 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXI

31 January 2024 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications X

27 January 2024 | San Francisco, California, United States

High-Speed Biomedical Imaging and Spectroscopy IX

27 January 2024 | San Francisco, California, United States

Advances in Microscopic Imaging

28 June 2023 | Munich, Germany

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXX

1 February 2023 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications IX

28 January 2023 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIX

26 January 2022 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VIII

22 January 2022 | San Francisco, California, United States

Advances in Microscopic Imaging

20 June 2021 | Online Only, Germany

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII

6 March 2021 | Online Only, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VII

6 March 2021 | Online Only, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVII

4 February 2020 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications VI

1 February 2020 | San Francisco, California, United States

Preclinical and Clinical Optical Diagnostics

23 June 2019 | Munich, Germany

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI

5 February 2019 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications V

2 February 2019 | San Francisco, California, United States

MOEMS and Miniaturized Systems XVII

30 January 2018 | San Francisco, California, United States

Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXV

29 January 2018 | San Francisco, California, United States

Molecular-Guided Surgery: Molecules, Devices, and Applications IV

27 January 2018 | San Francisco, California, United States

Clinical and Preclinical Optical Diagnostics

25 June 2017 | Munich, Germany

MOEMS and Miniaturized Systems XVI

30 January 2017 | San Francisco, California, United States

MOEMS and Miniaturized Systems XV

15 February 2016 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

15 February 2016 | San Francisco, California, United States

Clinical and Biomedical Spectroscopy and Imaging IV

22 June 2015 | Munich, Germany

MOEMS and Miniaturized Systems XIV

9 February 2015 | San Francisco, California, United States

MOEMS and Miniaturized Systems XIII

3 February 2014 | San Francisco, California, United States

MOEMS and Miniaturized Systems XII

4 February 2013 | San Francisco, California, United States

Showing 5 of 30 Conference Committees

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